3-Methoxypropylamine → HCID 90427351, compound

HRID 2278934Notes

Reaction equation

HRID 2278934 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH2:6].[Cl:7][CH2:8][CH2:9][N:10]=[C:11]=[O:12]>C1COCC1>[Cl:7][CH2:8][CH2:9][NH:10][C:11]([NH:6][CH2:5][CH2:4][CH2:3][O:2][CH3:1])=[O:12]

Participants

4

Reactant 2

HCID 16723-MethoxypropylamineHCID 160352-Chloroethyl isocyanate

Product 1

HCID 90427351HCID 90427351, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3-methoxypropylamine (0.45 mL, 4.39 mmol) in THF (15 mL) was treated with 2-chloroethylisocyanate (0.35 mL, 4.10 mmol), stirred at RT for 3 h and concentrated to dryness to afford 1-(2-chloroethyl)-3-(3-methoxypropyl)urea (100% yield assumed) as a white solid. MS (ESI) m/z: 195.1 (M+H+).

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-ab085320ef1749a8a1a2798955f76256
Source dataset
uspto-grants-2015_09
Patent number
US09133183B2

Reaction notes

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