反应详情

A 0° C. suspension of 1-(2-chloroethyl)-3-isopropylurea (6.00 g, 36.4 mmol) in THF (60 mL) was treated with NaH (60% in mineral oil, 2.50 g, 104 mmol) and stirred at RT overnight. The mixture was concentrated to dryness, treated with satd. NH4Cl, extracted with EtOAc (3×) and the combined organics were dried over Na2SO4 and concentrated to dryness to afford 1-isopropylimidazolidin-2-one (3.21 g, 69%) as a waxy solid. MS (ESI) m/z: 129.1 (M+H+).

1. concentrationThe mixture was concentrated to dryness
2. additiontreated with satd
3. extractionNH4Cl, extracted with EtOAc (3×)
4. dry with materialthe combined organics were dried over Na2SO4
5. concentrationconcentrated to dryness