Hydrochloric Acid → HCID 178501523, compound

HRID 2279149Notes

Reaction equation

HRID 2279149 reaction equation
[CH3:1][O:2][C:3](=[O:42])[CH2:4][N:5]1[CH2:10][C:9]([CH3:12])([CH3:11])[N:8]([CH2:13][C:14]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([O:26]COC)=[CH:22][CH:21]=3)[N:17]=[C:16]3[N:30](C4CCCCO4)[N:31]=[C:32]([CH3:33])[C:15]=23)[CH2:7][C:6]1([CH3:41])[CH3:40].Cl>>[CH3:1][O:2][C:3](=[O:42])[CH2:4][N:5]1[CH2:10][C:9]([CH3:12])([CH3:11])[N:8]([CH2:13][C:14]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=3)[N:17]=[C:16]3[NH:30][N:31]=[C:32]([CH3:33])[C:15]=23)[CH2:7][C:6]1([CH3:41])[CH3:40]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 90013949HCID 90013949, compound

Product 1

HCID 178501523HCID 178501523, compound

Procedure

78 mg of {4-[6-(4-Methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,2,5,5-tetramethyl-piperazin-1-yl}-acetic acid methyl ester were reacted with hydrochloric acid (4M in dioxane) and the volatiles were removed after 5 h. After purification by preparative HPLC 14 mg (21%) of the title compound were obtained.

Workup

  1. customthe volatiles were removed after 5 h
  2. customAfter purification by preparative HPLC 14 mg (21%) of the title compound
  3. customwere obtained

Sources & evidence

ORD record
ord-2e42a60c19db4bbfba2f907ab24d247d
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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