Hydrochloric Acid → HCID 178465270, compound

HRID 2279152Notes

Reaction equation

HRID 2279152 reaction equation
[CH2:1]([NH:3][C:4]([N:6]1[CH2:11][C:10]([CH3:13])([CH3:12])[N:9]([CH2:14][C:15]2[CH:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([O:27]COC)=[CH:23][CH:22]=3)[N:18]=[C:17]3[N:31](C4CCCCO4)[N:32]=[C:33]([CH3:34])[C:16]=23)[CH2:8][C:7]1([CH3:42])[CH3:41])=[O:5])[CH3:2].Cl>O1CCOCC1>[CH2:1]([NH:3][C:4]([N:6]1[CH2:11][C:10]([CH3:13])([CH3:12])[N:9]([CH2:14][C:15]2[CH:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=3)[N:18]=[C:17]3[NH:31][N:32]=[C:33]([CH3:34])[C:16]=23)[CH2:8][C:7]1([CH3:41])[CH3:42])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90014241HCID 90014241, compound

Product 1

HCID 178465270HCID 178465270, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

325 mg of 4-[6-(4-Methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,2,5,5-tetramethyl-piperazine-1-carboxylic acid ethylamide in 2 ml of dioxane were reacted with 2 ml hydrochloric acid (4M in dioxane). After 4 h at rt the volatiles were removed in vacuo. After purification by preparative HPLC 142 mg (56%) of the title compound were obtained.

Workup

  1. customAfter 4 h at rt the volatiles were removed in vacuo
  2. customAfter purification by preparative HPLC 142 mg (56%) of the title compound
  3. customwere obtained

Sources & evidence

ORD record
ord-475a637c778a44ca86d92607e322f85a
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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