Hydrochloric Acid → HCID 178496353, compound

HRID 2279155Notes

Reaction equation

HRID 2279155 reaction equation
[CH3:1][O:2][CH2:3][C:4]([N:6]1[CH2:11][C:10]([CH3:13])([CH3:12])[N:9]([CH2:14][C:15]2[CH:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([O:27]COC)=[CH:23][CH:22]=3)[N:18]=[C:17]3[N:31](C4CCCCO4)[N:32]=[C:33]([CH3:34])[C:16]=23)[CH2:8][C:7]1([CH3:42])[CH3:41])=[O:5].Cl>O1CCOCC1>[OH:27][C:24]1[CH:23]=[CH:22][C:21]([C:19]2[N:18]=[C:17]3[NH:31][N:32]=[C:33]([CH3:34])[C:16]3=[C:15]([CH2:14][N:9]3[C:10]([CH3:13])([CH3:12])[CH2:11][N:6]([C:4](=[O:5])[CH2:3][O:2][CH3:1])[C:7]([CH3:42])([CH3:41])[CH2:8]3)[CH:20]=2)=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90014275HCID 90014275, compound

Product 1

HCID 178496353HCID 178496353, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

93 mg of 2-Methoxy-1-{4-[6-(4-methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,2,5,5-tetramethyl-piperazin-1-yl}-ethanone were dissolved in 2.5 ml of dioxane and reacted with 2 ml hydrochloric acid (4M in dioxane). The volatiles were removed after 16 h. After purification by preparative HPLC 25 mg of the title compound were obtained.

Workup

  1. customThe volatiles were removed after 16 h
  2. customAfter purification by preparative HPLC 25 mg of the title compound
  3. customwere obtained

Sources & evidence

ORD record
ord-b10703fea0fd4bd984fc67ece813bbcf
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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