反应详情

温度

0 °C

Diisopropyl azodicarboxylate (DIAD, 1 eq) is added dropwise to a well-stirred solution of triphenylphosphine (1 eq) in THF (0.4 M) at 0° C. under nitrogen. After completion of the addition, the mixture is stirred at 0° C. for an additional 30 min. The white solid obtained is collected by filtration (use medium sized fitted filters) and washed with cold anhydrous THF until the washes are colorless. Finally, the white precipitate is washed once with anhydrous Et2O. The adduct is then dried well in vacuo, and stored under nitrogen. (It is important to store this reagent under anhydrous conditions!) The adduct can be used in place of the separately added reagents in Mitsunobu-type reactions.

1. additionAfter completion of the addition
2. customThe white solid obtained
3. filtrationis collected by filtration (use medium sized fitted filters)
4. washwashed with cold anhydrous THF until the washes
5. washFinally, the white precipitate is washed once with anhydrous Et2O
6. customThe adduct is then dried well in vacuo