Hydrochloric Acid → HCID 68294268, compound

HRID 2279476Notes

Reaction equation

HRID 2279476 reaction equation
[OH:1][CH:2]1[C:11]2[CH:10]=[N:9][C:8]([NH:12][CH:13]([CH3:15])[CH3:14])=[N:7][C:6]=2[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:23]>O1CCOCC1>[ClH:23].[CH:13]([NH:12][C:8]1[N:9]=[CH:10][C:11]2[CH:2]([OH:1])[CH2:3][NH:4][CH2:5][C:6]=2[N:7]=1)([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68294558HCID 68294558, compound

Product 1

HCID 68294268HCID 68294268, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 128 (400 mg, 1.30 mmol) and 4 N HCl in dioxane (4 mL) was stirred for 1 h. The reaction was concentrated to afford crude 2-(isopropylamino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-5-ol hydrochloride (130) which was used without additional purification.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-f011169cea54430f81947d3631002776
Source dataset
uspto-grants-2015_09
Patent number
US09133187B2

Reaction notes

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