Hydrochloric Acid → HCID 86705500, compound

HRID 2279506Notes

Reaction equation

HRID 2279506 reaction equation
[F:1][C:2]1([F:26])[C:11]2[CH:10]=[N:9][C:8]([NH:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[N:7][C:6]=2[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:27].CC(O)C>C(Cl)Cl>[ClH:27].[F:26][C:2]1([F:1])[C:11]2[CH:10]=[N:9][C:8]([NH:12][CH:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)=[N:7][C:6]=2[CH2:5][NH:4][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 68294431HCID 68294431, compound

Product 1

HCID 86705500HCID 86705500, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 206 (215 mg, 0.5805 mmol) in DCM (4 mL) at RT under nitrogen was added 5M HCl in IPA (1.161 mL, 5.805 mmol) by pipet. After stirring overnight, the reaction was concentrated to dryness by rotovap and high vacuum to afford 106 mg (100%) of 5,5-difluoro-N-(tetrahydro-2H-pyran-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-amine hydrochloride (208) which was used without additional purification.

Workup

  1. concentrationthe reaction was concentrated to dryness by rotovap and high vacuum

Sources & evidence

ORD record
ord-c2a99560d6ba4982b721d9fbad98baed
Source dataset
uspto-grants-2015_09
Patent number
US09133187B2

Reaction notes

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