Trifluoroacetic acid → HCID 86705574, compound

HRID 2279592Notes

Reaction equation

HRID 2279592 reaction equation
[OH:1][CH2:2][C@@H:3]([NH:5][C:6]1[CH:15]=[C:14]2[C:9]([CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13]2)=[CH:8][N:7]=1)[CH3:4].[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>>[F:26][C:25]([F:28])([F:27])[C:23]([OH:29])=[O:24].[CH:8]1[C:9]2[CH2:10][CH2:11][NH:12][CH2:13][C:14]=2[CH:15]=[C:6]([NH:5][C@@H:3]([CH3:4])[CH2:2][OH:1])[N:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68294972HCID 68294972, compound

Product 1

HCID 86705574HCID 86705574, compound

Procedure

A solution of 326 (56 mg, 0.18 mmol) and TFA (2 mL) and was stirred at RT for 45 min. The reaction was concentrated to provide crude (S)-2-(5,6,7,8-tetrahydro-2,6-naphthyridin-3-ylamino)propan-1-ol 2,2,2-trifluoroacetate (328) which was used in the nest step without further purification.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-ff63dda537324b709284f233fa31dd32
Source dataset
uspto-grants-2015_09
Patent number
US09133187B2

Reaction notes

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