Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate → HCID 59579876, compound

HRID 2279647Notes

Reaction equation

HRID 2279647 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7](=[S:9])[NH2:8].[CH2:10]([O:12][C:13](=[O:22])[CH:14](Cl)[C:15](=O)[C:16]([F:19])([F:18])[F:17])[CH3:11]>CN(C=O)C>[CH2:10]([O:12][C:13]([C:14]1[S:9][C:7]([C:2]2[N:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[N:8][C:15]=1[C:16]([F:17])([F:18])[F:19])=[O:22])[CH3:11]

Participants

4

Reactant 2

HCID 2737165Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoateHCID 23273397Pyrimidine-2-carbothioamide

Product 1

HCID 59579876HCID 59579876, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 2-pyrimidinecarbothioamide (2 g) and 2-chloro-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester (3.2 g) in 10 mL of DMF is heated at 110° C. with stirring overnight. The mixture is concentrated under vacuum, and purified on silica gel column to afford the title compound.

Workup

  1. concentrationThe mixture is concentrated under vacuum
  2. custompurified on silica gel column

Sources & evidence

ORD record
ord-fff039fd3a8c4c6a8280c0674ddc2abd
Source dataset
uspto-grants-2015_09
Patent number
US09133204B2

Reaction notes

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