反应详情

10-Azidodecanoic acid (2.0 g, 9.5 mmol) in THF (50 mL) is treated with tributylstannyl acetylene (2.99 g, 9.5 mmol) copper(I)iodide (90 mg 0.47 mmol) and triethylamine (256 mg, 2.54 mmol) at room temperature with constant stirring for 24 h. The reaction is then filtered through celite and concentrated in vacuo to a gum, and then chromatographed on silica in a gradient of 10-40% ethyl acetate in petrol. The main fraction is collected and concentrated in vacuo to give 10-(4-tributylstannyl-[1,2,3]triazol-1-yl)-decanoic acid (3.22 g, 0.8 mmol).

1. filtrationThe reaction is then filtered through celite and
2. concentrationconcentrated in vacuo to a gum
3. customchromatographed on silica in a gradient of 10-40% ethyl acetate in petrol
4. customThe main fraction is collected
5. concentrationconcentrated in vacuo