HCID 71208067, compound → HCID 71208634, compound

HRID 2280249Notes

Reaction equation

HRID 2280249 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH:24]3[CH2:30][O:29][CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25]3)[N:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([O:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:13][CH:12]=3)[C:3]=12>CC(C)=O.Cl>[O:29]1[CH2:30][CH:24]([N:8]2[C:4]3=[N:5][CH:6]=[N:7][C:2]([NH2:1])=[C:3]3[C:10]([C:11]3[CH:12]=[CH:13][C:14]([O:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:15][CH:16]=3)=[N:9]2)[CH2:25][NH:26][CH2:27][CH2:28]1

Participants

4

Reactant 1

HCID 71208067HCID 71208067, compound

Product 1

HCID 71208634HCID 71208634, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 313Hydrochloric AcidSolvent

Conditions

Temperature
45 °C

Procedure

tert-butyl 6-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1,4-oxazepane-4-carboxylate is dissolved in acetone and 6N aqueous hydrochloric acid. The reaction is then heated at 45° C. which yielded a precipitate. After 2.5 hours, the precipitate is collected by vacuum filtration, washed with a minimal amount of acetone and dried on the lyophilizer to afford title compound.

Workup

  1. customyielded a precipitate
  2. filtrationthe precipitate is collected by vacuum filtration
  3. washwashed with a minimal amount of acetone
  4. customdried on the lyophilizer

Sources & evidence

ORD record
ord-9b20193e3d0944f7aaaecf9d9c893d8d
Source dataset
uspto-grants-2015_09
Patent number
US09138436B2

Reaction notes

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