Acetaldehyde → Cyclohexyl-(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine

HRID 22803Notes

Reaction equation

HRID 22803 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[CH:9]1([N+:15]#[C-:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1.[CH:17](=O)[CH3:18]>Cl(O)(=O)(=O)=O>[CH:9]1([NH:15][C:16]2[N:3]3[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]3=[N:1][C:17]=2[CH3:18])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 177AcetaldehydeHCID 15332-Amino-4-methylpyridineHCID 79129Cyclohexyl isocyanide

Product 1

HCID 644816Cyclohexyl-(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound (18) was prepared according to the general synthesis instructions from 1.0 ml of 2-amino-4-methylpyridine solution (0.1 M, DCM), 0.575 ml of cyclohexyl isocyanide solution (0.2 M, DCM), 0.500 ml of acetaldehyde solution (0.3 M, DCM), and 10 μl of perchloric acid (w=20%).

Sources & evidence

ORD record
ord-41319b1d19b845a58a7a274b9903029f
Source dataset
uspto-grants-2005_02
Patent number
US06849642B2

Reaction notes

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