Hydrochloric Acid → HCID 58714317, compound

HRID 228075Notes

Reaction equation

HRID 228075 reaction equation
C(OC([NH:8][C@H:9]([CH2:28][C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=1)[C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:27]=[CH:26][CH:25]=[CH:24][C:19]=2[C:20]([O:22][CH3:23])=[O:21])[CH2:14][CH2:13]1)=[O:11])=O)(C)(C)C.Cl>CCOC(C)=O>[NH2:8][C@H:9]([CH2:28][C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=1)[C:10]([N:12]1[CH2:13][CH2:14][N:15]([C:18]2[CH:27]=[CH:26][CH:25]=[CH:24][C:19]=2[C:20]([O:22][CH3:23])=[O:21])[CH2:16][CH2:17]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58714324HCID 58714324, compound

Product 1

HCID 58714317HCID 58714317, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a 25 mL round-bottomed flask equipped with magnetic stirring was added methyl 2-(4-{(2R)-2-[(tert-butoxy)carbonylamino]-3-(4-chlorophenyl)propanoyl}-piperazinyl)benzoate (3.2 g, 6.4 mmol). A satd soln of HCl in EtOAc (15 mL) was added, and the mixture was stirred at RT for 1 h. The title compound, as the hydrochloride salt, was isolated by filtration as a white solid (2.6 g). MS (ESI, pos. ion) m/z: 402 (M+H). Calc'd for C21H24ClN3O3: 401.15.

Workup

  1. customTo a 25 mL round-bottomed flask equipped
  2. stirringthe mixture was stirred at RT for 1 h

Sources & evidence

ORD record
ord-0bc5a8085884425980af5c079a1e6b06
Source dataset
uspto-grants-2009_07
Patent number
US07560460B2

Reaction notes

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