Dimethylformamide dimethyl acetal → HCID 75201679, compound

HRID 2281080Notes

Reaction equation

HRID 2281080 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8]([Br:10])[CH:7]=[C:6]([F:11])[C:3]=1[C:4]#[N:5].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[Br:10][C:8]1[CH:7]=[C:6]([F:11])[C:3]([C:4]#[N:5])=[C:2]([N:1]=[CH:14][N:15]([CH3:17])[CH3:16])[CH:9]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 56973649HCID 56973649, compound

Product 1

HCID 75201679HCID 75201679, compound

Conditions

Temperature
120 °C

Procedure

A mixture of 17.0 g (79.1 mmol) 2-amino-4-bromo-6-fluoro-benzonitrile and 140 ml of N,N-dimethylformamide dimethyl acetal is heated to 120° C. for 2 h. After cooling RT the solvent is evaporated and the residual taken up in diethyl ether, filtered and dried.

Workup

  1. temperatureAfter cooling RT the solvent
  2. customis evaporated
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-20915ce2c7c34cc79ed323c87645e781
Source dataset
uspto-grants-2015_09
Patent number
US09139577B2

Reaction notes

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