反应详情

6.61 g (24.84 mmol) 5-[1-(5-fluoro-2-nitro-phenoxy)ethyl]-3-methyl-isoxazole and 24.66 g (109.30 mmol) tin(II)chloride dihydrate in EtOAc are stirred for 1 h at reflux. The mixture is diluted with 180 mL EtOAc and 180 mL aq. NaOH (4M). The organic layer is separated and the aqueous layer is extracted with EtOAc. The combined organic layers are washed with water and brine, separated, dried and evaporated. The residue is purified by FC.

1. temperatureat reflux
2. customThe organic layer is separated
3. extractionthe aqueous layer is extracted with EtOAc
4. washThe combined organic layers are washed with water and brine
5. customseparated
6. customdried
7. customevaporated
8. customThe residue is purified by FC