Hydrochloric Acid → HCID 117772544, compound

HRID 2281090Notes

Reaction equation

HRID 2281090 reaction equation
[N+:1]([C:4]1[C:5]([O:10][C@H:11]([CH3:16])[C:12]([O:14]C)=[O:13])=[N:6][CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[OH-].[Na+].Cl>CO>[N+:1]([C:4]1[C:5]([O:10][C@H:11]([CH3:16])[C:12]([OH:14])=[O:13])=[N:6][CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 129387551HCID 129387551, compound

Product 1

HCID 117772544HCID 117772544, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3.0 g (13.3 mmol) of methyl (2R)-2-[(3-nitro-2-pyridyl)oxy]propanoate and 5.0 ml 4 mol/l aq. NaOH solution in methanol are stirred at RT for 30 min. 5.0 ml 4 mol/l aq. HCl are added and the reaction mixture concentrated. The precipitate is filtered off, dissolved in DCM, dried and evaporated yielding (2R)-2-[(3-nitro-2-pyridyl)oxy]propanoic acid.

Workup

  1. concentrationthe reaction mixture concentrated
  2. filtrationThe precipitate is filtered off
  3. dissolutiondissolved in DCM
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-9c2db01cbf5640aca4f99f357fc700f2
Source dataset
uspto-grants-2015_09
Patent number
US09139577B2

Reaction notes

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