Ethanamine, 2,2,2-trifluoro- → HCID 117774392, compound

HRID 2281108Notes

Reaction equation

HRID 2281108 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:14]=3[O:15][C@H:16]([CH3:20])[C:17](O)=[O:18])=[N:7][CH:8]=[N:9]2)=[C:4]([F:26])[CH:3]=1.CCN(C(C)C)C(C)C.[F:36][C:37]([F:41])([F:40])[CH2:38][NH2:39].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>O.CN(C=O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:14]=3[O:15][C@H:16]([CH3:20])[C:17]([NH:39][CH2:38][C:37]([F:41])([F:40])[F:36])=[O:18])=[N:7][CH:8]=[N:9]2)=[C:4]([F:26])[CH:3]=1

Participants

7

Reactant 4

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 117772402HCID 117772402, compound

Product 1

HCID 117774392HCID 117774392, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a mixture of 300 mg (0.78 mmol) (2R)-2-[2-[(7-bromo-5-fluoro-quinazolin-4-yl)amino]-5-fluoro-phenoxy]propanoic acid and DMF, 0.3 ml (1.8 mmol) DIPEA, 105 mg (0.89 mmol) 2,2,2-trifluoro-ethylamine and 344 mg (0.9 mmol) HATU are added. The mixture is stirred at RT for 3 h, water is added and the precipitate is filtered and dried.

Workup

  1. additionare added
  2. filtrationthe precipitate is filtered
  3. customdried

Sources & evidence

ORD record
ord-b273475e6b7b423999cf3caf7fcdc225
Source dataset
uspto-grants-2015_09
Patent number
US09139577B2

Reaction notes

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