Lithium Hydroxide → HCID 63154507, compound

HRID 2281300Notes

Reaction equation

HRID 2281300 reaction equation
[N:1]1([C:6]2[CH:7]=[N:8][CH:9]=[C:10]([CH:15]=2)[C:11]([O:13]C)=[O:12])[CH:5]=[N:4][N:3]=[N:2]1.[OH-].[Li+]>C1COCC1.O>[N:1]1([C:6]2[CH:7]=[N:8][CH:9]=[C:10]([CH:15]=2)[C:11]([OH:13])=[O:12])[CH:5]=[N:4][N:3]=[N:2]1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 89543726HCID 89543726, compound

Product 1

HCID 63154507HCID 63154507, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

The methyl 5-(1H-tetrazol-1-yl)nicotinate obtained in step A was dissolved in THF (50 mL) and treated with 1N lithium hydroxide (50 mL) and stirred for 1 hour. The mixture was diluted with water and the resulting solid isolated by filtration and drying under high vacuum to provide 5-(1H-tetrazol-1-yl)nicotinic acid.

Workup

  1. customthe resulting solid isolated by filtration
  2. customdrying under high vacuum

Sources & evidence

ORD record
ord-42d0212c45394106b3802258a2494f35
Source dataset
uspto-grants-2015_09
Patent number
US09139585B2

Reaction notes

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