Triethylamine → HCID 86636614, compound

HRID 2281435Notes

Reaction equation

HRID 2281435 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH:10]=[C:9]([CH3:11])[NH:8][C:6]=2[N:7]=1.[CH:13]1([NH2:17])[CH2:16][CH2:15][CH2:14]1.C(N(CC)CC)C>C(O)CCC>[Cl:1][C:2]1[N:3]=[C:4]([NH:17][CH:13]2[CH2:16][CH2:15][CH2:14]2)[C:5]2[CH:10]=[C:9]([CH3:11])[NH:8][C:6]=2[N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 75645CyclobutylamineHCID 567638132,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 86636614HCID 86636614, compoundYield 44.9%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A solution of 2,4-dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine (190 mg, 0.94 mmol), cyclobutylamine (0.160 mL, 1.88 mmol) and triethylamine (0.200 mL, 1.44 mmol) in nBuOH (6 mL) was stirred at 70° C. overnight. It was then purified by HPLC to give 2-chloro-N-cyclobutyl-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (100 mg).

Workup

  1. customIt was then purified by HPLC

Sources & evidence

ORD record
ord-5b35eadaa06945f08d5b4a6bdc06f4d0
Source dataset
uspto-grants-2015_09
Patent number
US09139581B2

Reaction notes

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