反应详情

To a suspension of above 2-benzoxy-N-methyl-N-(4-nitrophenyl)acetamide in EtOH (8 mL) and H2O (4 mL) was added ammonium formate (1.3 g, 20 mmol) and Fe (0.47 g, 8.4 mmol). After heating at reflux for 2 h, the reaction was cooled to room temperature, iron was filtered off, and the filtrate was diluted with EtOAc and water, EtOAc layer was separated and the aqueous layer was further extracted with EtOAc, organic layers were combined, dried over Na2SO4, and was concentrated under vacuo to provide 2-benzoxy-N-methyl-N-(4-aminophenyl)acetamide (0.4 g, 53%).

1. temperatureAfter heating
2. temperatureat reflux for 2 h
3. filtrationiron was filtered off
4. additionthe filtrate was diluted with EtOAc and water, EtOAc layer
5. customwas separated
6. extractionthe aqueous layer was further extracted with EtOAc, organic layers
7. dry with materialdried over Na2SO4
8. concentrationwas concentrated under vacuo