Hydrochloric Acid → HCID 86674623, compound

To a 50 mL round bottom flask adapted for magnetic stirring and fitted with a nitrogen inlet tube was charged 5-(3-chlorophenyl)-3-hydroxypyridine-2-carboxylic acid, 3, (1 gm, 4 mmol), N,N′-carbonyldiimidazole (CDI) (0.97 g, 6 mmol) and dimethyl sulfoxide (5 mL). The reaction mixture was stirred at 45° C. for about 1 hour then cooled to room temperature. Glycine methyl ester hydrochloride (1.15 g, 12 mmol) is added followed by the dropwise addition of diisopropylethylamine (3.2 mL, 19 mmol). The mixture was then stirred for 2.5 hours at room temperature after which water (70 mL) was added. The contents of the reaction flask was cooled to 0° C. to 5° C. and 1N HCl was added until the solution pH is approximately 2. The solution was extracted with dichloromethane (100 mL) and the organic layer was dried over MgSO4 for 16 hours. Silica gel (3 g) is added and the solution slurried for 2 hours after which the solids are removed by filtration. The filtrate is concentrated to dryness under reduced pressure and the resulting residue was slurried in methanol (10 mL) for two hours. The resulting solid was collected by filtration and washed with cold methanol (20 mL) then hexane and the resulting cake is dried to afford 0.85 g of the desired product as an off-white solid. The filtrate was treated to afford 0.026 g of the desired product as a second crop. The combined crops afford 0.88 g (68% yield) of the desired product. 1H NMR (DMSO-d6) δ 12.3 (s, 1H), 9.52 (t, 1H), 8.56 (d, 1H), 7.93 (s, 1H), 7.80 (q, 2H), 7.55 (t, 2H), 4.12 (d, 2H), and 3.69 (s, 3H).

1. customTo a 50 mL round bottom flask adapted
2. customfitted with a nitrogen inlet tube
3. stirringThe reaction mixture was stirred at 45° C. for about 1 hour
4. additionwas added
5. temperatureThe contents of the reaction flask was cooled to 0° C. to 5° C.
6. extractionThe solution was extracted with dichloromethane (100 mL)
7. dry with materialthe organic layer was dried over MgSO4 for 16 hours
8. additionSilica gel (3 g) is added
9. customafter which the solids are removed by filtration
10. concentrationThe filtrate is concentrated to dryness under reduced pressure
11. waitthe resulting residue was slurried in methanol (10 mL) for two hours
12. filtrationThe resulting solid was collected by filtration
13. washwashed with cold methanol (20 mL)
14. dry with materialhexane and the resulting cake is dried

ORD record

ord-42224421a9e9474aabcb47327c17aa52

Source dataset

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09145366B2