Urea → HCID 3867953, compound

HRID 2283236Notes

Reaction equation

HRID 2283236 reaction equation
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][C:15](N)=[O:16]>>[C:15](=[O:16])([O:13][C:10]1[CH:9]=[CH:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:12][CH:11]=1)[NH2:14]

Participants

3

Reactant 2

HCID 1176UreaHCID 71034-Hydroxybiphenyl

Product 1

HCID 3867953HCID 3867953, compoundYield 90%

Procedure

6298 g of 4-phenyl phenol and 444 g of urea were charged into an autoclave (Toyo Koatsu Inc., Japan) equipped with a thermometer, stirrer, reflux condenser and gas feed tube and having an internal volume of 12 L followed by stirring at normal pressure while bubbling nitrogen gas with a capillary tube at the rate of 100 L/hr and carrying out the reaction at 140° C. When a portion of the reaction liquid was removed 10 hours later and analyzed by liquid chromatography, the formation of (4-phenylphenyl) carbamate was confirmed. The yield was about 90% based on the charged amount of urea.

Workup

  1. customequipped with a thermometer, stirrer
  2. temperaturereflux condenser and gas feed tube
  3. customwhile bubbling nitrogen gas with a capillary tube at the rate of 100 L/hr
  4. customthe reaction at 140° C
  5. customWhen a portion of the reaction liquid
  6. customwas removed 10 hours later

Sources & evidence

ORD record
ord-ea1f59aa98b54e0f97b15629ac350553
Source dataset
uspto-grants-2015_09
Patent number
US09145357B2

Reaction notes

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