反应详情

Sulfurylchloride (0.21 mL, 2.6 mmol) was added to a solution of triphenylphosphine (0.68 g, 2.5 mmol) in CH2Cl2 (10 mL) at 0° C. The ice-bath was then removed and (E)-2-(4-benzofuran-2-ylphenyl)ethenesulfonic acid (0.38 g, 1.18 mmol) was added and the resulting mixture was stirred for 6 h at RT. A catalytic amount of tetrabutyl ammonium iodide was added and the reaction was stirred for an additional 12 h. The mixture was then filtered and the filtrate was concentrated in vacuo and the product was purified by column chromatography eluting with 20% EtOAc/hexanes to give the product as a yellow solid (0.27 g, 73%).

1. customThe ice-bath was then removed
2. stirringthe reaction was stirred for an additional 12 h
3. filtrationThe mixture was then filtered
4. concentrationthe filtrate was concentrated in vacuo
5. customthe product was purified by column chromatography
6. washeluting with 20% EtOAc/hexanes