HCID 42644132, compound → HCID 42644368, compound

HRID 2283283Notes

Reaction equation

HRID 2283283 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[S:10]([NH:13][C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=2[S:21]([NH2:24])(=[O:23])=[O:22])(=[O:12])=[O:11])=[CH:4][CH:3]=1.[H][H]>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=2[S:21]([NH2:24])(=[O:23])=[O:22])(=[O:11])=[O:12])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 42644132HCID 42644132, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 42644368HCID 42644368, compoundYield 49.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

2-[[(E)-2-(4-Chlorophenyl)ethenyl]sulfonylamino]-4-fluoro-benzenesulfonamide (120 mg, 0.31 mmol) was dissolved in ethyl acetate (5 ml) and subjected to the H-cube (1 ml/min, full hydrogen. 10% Pd/C). The product obtained was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (60 mg, 49%) as a white solid.

Workup

  1. customThe product obtained
  2. customwas purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

Sources & evidence

ORD record
ord-82fca00944f64ef6bfc4f313537c8b1d
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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