2-Aminobenzenesulfonamide → HCID 68782416, compound

HRID 2283312Notes

Reaction equation

HRID 2283312 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[CH:8][C:9]2[S:13][C:12]3[CH:14]=[CH:15][C:16]([S:18](Cl)(=[O:20])=[O:19])=[CH:17][C:11]=3[C:10]=2[CH:22]=1)(=[O:5])=[O:4].[NH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[S:30]([NH2:33])(=[O:32])=[O:31]>S1(CCCC1)(=O)=O.Cl>[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[CH:8][C:9]2[S:13][C:12]3[CH:14]=[CH:15][C:16]([S:18]([NH:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[S:30](=[O:32])(=[O:31])[NH2:33])(=[O:20])=[O:19])=[CH:17][C:11]=3[C:10]=2[CH:22]=1)(=[O:5])=[O:4]

Participants

5

Reactant 2

HCID 728942-AminobenzenesulfonamideHCID 86632007HCID 86632007, compound

Product 1

HCID 68782416HCID 68782416, compoundYield 72%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 31347SulfolaneSolvent

Procedure

8-(Methylsulfamoyl)dibenzo[b,d]thiophene-2-sulfonyl chloride (200 mg) was added to a solution of 2-aminobenzenesulfonamide (191 mg) in sulfolane (2 ml). The mixture was stirred at RT for 20 h then diluted with 1N hydrochloric acid. The solid was recovered, washed with 1N hydrochloric acid and dried to give the title compound (196 mg, 72%).

Workup

  1. customThe solid was recovered
  2. washwashed with 1N hydrochloric acid
  3. customdried

Sources & evidence

ORD record
ord-8957ec0dbe3c4fc5a1aee0ce33528e1b
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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