Ammonium Hydroxide → HCID 57750963, compound

HRID 2283366Notes

Reaction equation

HRID 2283366 reaction equation
[OH-].[NH4+:2].[N+:3]([C:6]1[CH:10]=[CH:9][S:8][C:7]=1[S:11](Cl)(=[O:13])=[O:12])([O-:5])=[O:4]>O1CCCC1>[N+:3]([C:6]1[CH:10]=[CH:9][S:8][C:7]=1[S:11]([NH2:2])(=[O:13])=[O:12])([O-:5])=[O:4]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 23120308HCID 23120308, compound

Product 1

HCID 57750963HCID 57750963, compoundYield 111.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ammonium hydroxide (28% aqueous, 2.4 mL, 17.57 mmol) was added to a stirred solution of 3-nitro-thiophene-2-sulfonyl chloride (1.00 g, 4.39 mmol) in tetrahydrofuran (50 mL) at room temperature. After 15 min the reaction mixture was concentrated under reduced pressure. The residue was triturated in methanol and dichloromethane. The solid was collected by filtration and dried to give 1.02 g (quantitative yield) of the title compound.

Workup

  1. concentrationAfter 15 min the reaction mixture was concentrated under reduced pressure
  2. customThe residue was triturated in methanol
  3. filtrationThe solid was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-b15ce050b8bd451c9ff956191e681f09
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

Loading…