Hydrogen Peroxide → HCID 59730281, compound

HRID 228357Notes

Reaction equation

HRID 228357 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[CH2:17][NH:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1.OO.C(=O)([O-])[O-:30].[K+].[K+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[CH2:17][NH:18][CH2:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[O:5][C:6]1[CH:7]=[CH:8][C:9]([C:10]([NH2:11])=[O:30])=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 59730195HCID 59730195, compound

Product 1

HCID 59730281HCID 59730281, compound

Procedure

The compound of step 1 above is subject to hydrolysis using hydrogen peroxide and potassium carbonate. The details of the hydrolysis procedure to form the amide form nitrile have been described exhaustively elsewhere in this document. Electrospray MS M+1 ion=381. 1H-NMR (CDCl3, 200 MHz): 7.92-7.85 (m, 2H), 7.39 (d, 1H, J=8.3 Hz), 7.30-7.12 (m, 5H), 7.06-6.91 (m, 4H), 3.84 (s, 2H), 2.83 (s, 4H).

Workup

  1. customThe details of the hydrolysis procedure

Sources & evidence

ORD record
ord-d61966d358584ad3a878f39bcbc2b208
Source dataset
uspto-grants-2009_07
Patent number
US07560463B2

Reaction notes

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