Trifluoroacetic acid → HCID 86682360, compound

HRID 2283608Notes

Reaction equation

HRID 2283608 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC(=O)[N:14]([S:20]([C:23]1[CH:28]=[C:27]([Cl:29])[C:26]([O:30][C:31]2[CH:36]=[C:35]([C:37]([F:40])([F:39])[F:38])[C:34]([F:41])=[CH:33][C:32]=2[C:42]2[CH:47]=[CH:46][N:45]=[N:44][CH:43]=2)=[CH:25][C:24]=1[F:48])(=[O:22])=[O:21])[C:15]1[N:16]=[CH:17][S:18][CH:19]=1)(C)(C)C>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:29][C:27]1[C:26]([O:30][C:31]2[CH:36]=[C:35]([C:37]([F:38])([F:40])[F:39])[C:34]([F:41])=[CH:33][C:32]=2[C:42]2[CH:47]=[CH:46][N:45]=[N:44][CH:43]=2)=[CH:25][C:24]([F:48])=[C:23]([S:20]([NH:14][C:15]2[N:16]=[CH:17][S:18][CH:19]=2)(=[O:22])=[O:21])[CH:28]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86682359HCID 86682359, compound

Product 1

HCID 86682360HCID 86682360, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (9 mL) was added to a solution of tert-butyl({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate (2.0 g, 3.1 mmol) in dichloromethane (20 mL). After 2 hours, the reaction mixture was concentrated in vacuo to afford the title compound as an amber foam (2.37 g).

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-09fa563456354647b8497f654f31f0db
Source dataset
uspto-grants-2015_09
Patent number
US09145407B2

Reaction notes

Loading…