HCID 90308781, compound → HCID 90308716, compound

HRID 2283712Notes

Reaction equation

HRID 2283712 reaction equation
[CH2:1]([N:3]1[C:11]2[C:6](=[C:7]([CH3:15])[CH:8]=[C:9]([N+:12]([O-])=O)[CH:10]=2)[CH:5]=[N:4]1)[CH3:2]>[Pd].C(OCC)(=O)C>[CH2:1]([N:3]1[C:11]2[C:6](=[C:7]([CH3:15])[CH:8]=[C:9]([NH2:12])[CH:10]=2)[CH:5]=[N:4]1)[CH3:2]

Participants

4

Reactant 1

HCID 90308781HCID 90308781, compound

Product 1

HCID 90308716HCID 90308716, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

10% Palladium on carbon (1.0 g) was added to a solution of 1-ethyl-4-methyl-6-nitro-1H-indazole obtained in the above-described Step 1 (975 mg) in ethyl acetate (10 mL), and the reaction solution was stirred under hydrogen atmosphere at room temperature overnight. The insolubles were filtrated, and the solvent was evaporated under vacuum to obtain 1-ethyl-4-methyl-1H-indazol-6-amine.

Workup

  1. filtrationThe insolubles were filtrated
  2. customthe solvent was evaporated under vacuum

Sources & evidence

ORD record
ord-65501ae3b5474f9587f9b02a27634654
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

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