HCID 66958288, compound → HCID 66959005, compound

HRID 2283781Notes

Reaction equation

HRID 2283781 reaction equation
[CH2:1]([C:3]1[N:7]([CH2:8][CH2:9][CH3:10])[N:6]=[C:5]([C:11]([NH2:13])=O)[CH:4]=1)[CH3:2]>P(Cl)(Cl)(Cl)=O>[CH2:1]([C:3]1[N:7]([CH2:8][CH2:9][CH3:10])[N:6]=[C:5]([C:11]#[N:13])[CH:4]=1)[CH3:2]

Participants

3

Reactant 1

HCID 66958288HCID 66958288, compound

Product 1

HCID 66959005HCID 66959005, compoundYield 98.7%

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideSolvent

Procedure

5-Ethyl-1-propyl-1H-pyrazole-3-carboxamide (5.50 g, 30.35 mmol) was treated with phosphorous oxychloride (20 mL) according to the procedure described in Part D of Examples 37-39 to yield 4.89 g of 5-ethyl-1-propyl-1H-pyrazole-3-carbonitrile as an oil.

Sources & evidence

ORD record
ord-92b5d0bda313494f8a4cfbc4971e1e2a
Source dataset
uspto-grants-2015_09
Patent number
US09145410B2

Reaction notes

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