HCID 66958629, compound → HCID 57717595, compound

HRID 2283806Notes

Reaction equation

HRID 2283806 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]2[N:10]([CH2:23][CH2:24][CH3:25])[N:11]=[C:12]3[C:21]=2[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[N:14]=[C:13]3[NH2:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>FC(F)(F)C(O)=O.[Pt](=O)=O>[CH:1]1([CH2:7][CH2:8][C:9]2[N:10]([CH2:23][CH2:24][CH3:25])[N:11]=[C:12]3[C:21]=2[C:20]2[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=2[N:14]=[C:13]3[NH2:22])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 66958629HCID 66958629, compound

Product 1

HCID 57717595HCID 57717595, compoundYield 52.7%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of 1-(2-phenylethyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine (prepared as described in Example 42, 400 mg, 1.21 mmol) and platinum (IV) oxide (200 mg) in trifluoroacetic acid (8 mL) was shaken under hydrogen pressure (50 psi, 3.4×105 Pa) on a Parr apparatus for 18 hours and worked up using the method described in Example 58 to afford 217 mg of 1-(2-cyclohexylethyl)-2-propyl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-c]quinolin-4-amine as a white powder, mp 173-174.5° C.

Sources & evidence

ORD record
ord-67fa0bafc4b94deab372e741d2f6ff4a
Source dataset
uspto-grants-2015_09
Patent number
US09145410B2

Reaction notes

Loading…