反应详情

温度

160 °C

A mixture of 3-bromo-4-chloropyridine (100.0 mg; 0.52 mmol; 1.0 eq.), 4-[4-(3-trifluoromethyl-phenyl)-1h-imidazol-2-yl]-piperidine (153.4 mg; 0.52 mmol; 1.0 eq.), N,N-diisopropylethylamine (0.26 ml; 1.56 mmol; 3.0 eq.) in NMP (2.0 ml) in a microwave vial was heated at 160° C. for 4 h. The reaction mixture was poured into water. The precipitate was filtered, washed with water and dried under vacuum to afford the title compound in 64% yield. LC-MS: (M+1=451, obsd.=451).

1. filtrationThe precipitate was filtered
2. washwashed with water
3. customdried under vacuum