Trifluoroacetic acid → HCID 22692035, compound

HRID 2284101Notes

Reaction equation

HRID 2284101 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[CH2:6][CH2:7][NH:8][C:9](=[O:20])[CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:12][CH2:11][CH2:10][C:9]([NH:8][CH2:7][CH2:6][C:5]1[CH:21]=[CH:22][CH:23]=[C:3]([O:2][CH3:1])[CH:4]=1)=[O:20]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86673951Carbamic acid, N-[3-[[2-(3-methoxyphenyl)ethyl]amino]-3-oxopropyl]-, 1,1-dimethylethyl ester

Product 1

HCID 22692035HCID 22692035, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

tert-butyl (3-((3-methoxyphenethyl)amino)-3-oxopropyl)carbamate was dissolved in dichloromethane (0.5 mL) then the solution was cooled to 0° C. in an ice bath. Trifluoroacetic acid (300 μL) was added then the solution was allowed to warm slowly to room temperature with stirring. Upon completion of the reaction the solvent is removed under reduced pressure to give crude product which is used without further purification.

Workup

  1. temperatureto warm slowly to room temperature
  2. customUpon completion of the reaction the solvent
  3. customis removed under reduced pressure
  4. customto give crude product which
  5. customis used without further purification

Sources & evidence

ORD record
ord-0f079fbe990847d9b8c77bbaddc2d28a
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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