反应详情

温度

0 °C

4-Chlorothiophenol (1.1 g, 7.61 mmol) was mixed with ethyl 4-chloro-acetoacetate (0.95 mL, 7.00 mmol) in CH2Cl2 (100 mL) at 0° C. Triethyl amine (1.5 mL, 10.8 mmol) was then added drop wise. After the resulting suspension was stirred at 0° C. for another 30 min, the reaction mixture was poured into water, and the aqueous layer was extracted with EtOAc. The combined organic layer was washed by saturated NaHCO3, HCl (0.25 N), brine, concentrated in vacuo, and purified by flash column chromatography (ethyl acetate/hexanes=1/9) to afford TC-I-164 (1.82 g, 96%) as light yellow oil. Exposure to hydrazine in refluxing ethanol, generated TC-II-165.

1. extractionthe aqueous layer was extracted with EtOAc
2. washThe combined organic layer was washed by saturated NaHCO3, HCl (0.25 N), brine
3. concentrationconcentrated in vacuo
4. custompurified by flash column chromatography (ethyl acetate/hexanes=1/9)
5. customto afford TC-I-164 (1.82 g, 96%) as light yellow oil