HCID 90052222, compound → HCID 90052109, compound

HRID 2284682Notes

Reaction equation

HRID 2284682 reaction equation
[F:1][C:2]([F:26])([CH:15]([F:25])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=1)[CH2:3][N:4]1C(=O)C2C(=CC=CC=2)C1=O>C(O)C.O1CCCC1.O.NN>[F:1][C:2]([F:26])([CH:15]([F:25])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=1)[CH2:3][NH2:4]

Participants

5

Reactant 1

HCID 90052222HCID 90052222, compound

Product 1

HCID 90052109HCID 90052109, compoundYield 65.6%

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolventHCID 24654Hydrazine hydrate (1:1)Solvent

Procedure

To a solution of 2-(2,2,3-trifluoro-3-(3-nitrophenyl)propyl)isoindoline-1,3-dione (C33, 531 mg) in ethanol (4 mL) and tetrahydrofuran (4 mL), hydrazine monohydrate (349 μL) was added at room temperature, and the mixture was stirred at the same temperature for 18 hours. The insoluble matter was removed by filtration, and then the solvent was evaporated under reduced pressure to obtain 2,2,3-trifluoro-3-(3-nitrophenyl)propan-1-amine (C34, 224 mg).

Workup

  1. customThe insoluble matter was removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c67f9246fbf74b67a5957172a5815951
Source dataset
uspto-grants-2015_09
Patent number
US09145415B2

Reaction notes

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