Toluene → HCID 178449832, compound

HRID 2284731Notes

Reaction equation

HRID 2284731 reaction equation
[NH2:1][C:2]([CH3:13])([CH3:12])[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].S([O-])([O-])(=O)=O.[Na+].[Na+].[C:21]1([CH3:27])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(=O)C1C=CC=CC=1>[CH:27](=[N:1]/[C:2]([CH3:13])([CH3:12])[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:8])([CH3:10])[CH3:9])\[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 1140TolueneHCID 24436Sodium SulfateHCID 17909918tert-butyl N-(2-amino-2-methylpropyl)carbamate

Product 1

HCID 178449832HCID 178449832, compound

Reagents, catalysts & solvents 1

HCID 240BenzaldehydeSolvent

Procedure

To a suspension of tert-butyl (2-amino-2-methylpropyl)carbamate (1.98 g) and anhydrous sodium sulfate (3.00 g) in toluene (5 mL), benzaldehyde (1.07 mL) was added at room temperature, and the mixture was stirred for 11 hours under reflux by heating. The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure to obtain (E)-tert-butyl (2-(benzylideneamino)-2-methylpropyl)carbamate (G8).

Workup

  1. additionwas added at room temperature
  2. temperatureunder reflux
  3. temperatureby heating
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-0db8ab7d317b42abb605884a8f0e2d1d
Source dataset
uspto-grants-2015_09
Patent number
US09145415B2

Reaction notes

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