反应详情

6,7-Dimethoxy-4-[(1H-5-indolyl)oxy]quinoline (50 mg) was dissolved in N,N-dimethylformamide (1 ml), and 60% sodium hydride (7 mg) was added, followed by stirring for 30 min under ice cooling. Methyl iodide (0.0107 ml) was added to the reaction solution, and the mixture was stirred under ice cooling for additional one hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using methanol-chloroform to give the title compound (32 mg, yield 62%).

1. stirringthe mixture was stirred under ice cooling for additional one hr
2. extractionthe mixture was extracted with ethyl acetate
3. washThe ethyl acetate layer was then washed with water and saturated brine
4. dry with materialwas dried over anhydrous sodium sulfate
5. customThe solvent was removed
6. distillationby distillation under the reduced pressure
7. customthe residue was purified by thin layer chromatography