2-Cyano-2-methyl-but-3-enoic acid tert-butyl ester → 2-Cyano-2-methyl-but-3-enoic acid

HRID 2285368Notes

Reaction equation

HRID 2285368 reaction equation
C([O:5][C:6](=[O:13])[C:7]([C:11]#[N:12])([CH3:10])[CH:8]=[CH2:9])(C)(C)C>Cl.O1CCOCC1>[C:11]([C:7]([CH3:10])([CH:8]=[CH2:9])[C:6]([OH:13])=[O:5])#[N:12]

Participants

4

Reactant 1

HCID 867096622-Cyano-2-methyl-but-3-enoic acid tert-butyl ester

Product 1

HCID 867096632-Cyano-2-methyl-but-3-enoic acid

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

2-Cyano-2-methyl-but-3-enoic acid tert-butyl ester (362 mg, 2 mmol) was suspended in 4 M hydrochloric acid in dioxane (10 mL) and the reaction mixture stirred for 38 h and then evaporated. The residue was used directly in the next reaction.

Workup

  1. customevaporated
  2. customThe residue was used directly in the next reaction

Sources & evidence

ORD record
ord-56f37af3f8c64a289aacb23f75ee8d6c
Source dataset
uspto-grants-2015_09
Patent number
US09145441B2

Reaction notes

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