Hydrochloric Acid → HCID 54285611, compound

HRID 2285745Notes

Reaction equation

HRID 2285745 reaction equation
N1C=CC=CC=1.[Cl:7][C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][CH2:16][OH:17])[CH:11]=[CH:12][CH:13]=1.[C:18]1([CH3:28])[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1.Cl>C(Cl)(Cl)Cl.O>[Cl:7][C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][CH2:16][O:17][S:24]([C:21]2[CH:22]=[CH:23][C:18]([CH3:28])=[CH:19][CH:20]=2)(=[O:26])=[O:25])[CH:11]=[CH:12][CH:13]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 99896673-(3-Chlorophenyl)propan-1-ol

Product 1

HCID 54285611HCID 54285611, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6212ChloroformSolvent

Procedure

86 ml of pyridine are added dropwise to 90 g of 3-(3-chlorophenyl)propan-1-ol and 124 g of p-toluenesulfonic acid chloride in 300 ml of chloroform at 0° C. When the addition is complete, the mixture is stirred at room temperature for 3 hours, and the solution is poured into a mixture of 400 ml of water and 120 ml of concentrated hydrochloric acid. The organic phase is separated off, washed 3 times with water, dried over sodium sulfate and concentrated to a viscous oil in vacuo.

Workup

  1. additionWhen the addition
  2. customThe organic phase is separated off
  3. washwashed 3 times with water
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated to a viscous oil in vacuo

Sources & evidence

ORD record
ord-4504646ede9c428b86c058661fb3d690
Source dataset
uspto-grants-1982_04
Patent number
US04324796

Reaction notes

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