Sodium Hydroxide → Sodium 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate

HRID 2285752Notes

Reaction equation

HRID 2285752 reaction equation
C([O:3][C:4]([C:6]1([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:8][O:7]1)=[O:5])C.[OH-].[Na+:22]>O1CCCC1>[Cl:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:6]2([C:4]([O-:5])=[O:3])[CH2:8][O:7]2)=[CH:19][CH:18]=1.[Na+:22]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54217Ethyl 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate

Product 1

HCID 23676477Sodium 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 8.05 g of 2-[5-(4-chlorophenyl)pentyl]oxirane 2-carboxylic acid ethyl ester, 27 ml of tetrahydrofuran and 27 ml of 1 N sodium hydroxide solution is stirred for about 1 hour until a clear solution has formed. The solution is concentrated and the colorless residue is recrystallized from ethanol/diethyl ether. 6.5 g of the title compound of m.p. 136° to 142° C. are obtained.

Workup

  1. customhas formed
  2. concentrationThe solution is concentrated
  3. customthe colorless residue is recrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-237367ec042646e1a75527e0dfebf599
Source dataset
uspto-grants-1982_04
Patent number
US04324796

Reaction notes

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