Benzophenone, 2'-hydroxy-5'-methoxy- → HCID 24879062, compound

HRID 228594Notes

Reaction equation

HRID 228594 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[OH:16][C:17]1[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][C:18]=1[C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:20]>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[O:16][C:17]1[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][C:18]=1[C:19]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:20]

Participants

3

Reactant 2

HCID 26881Benzophenone, 2'-hydroxy-5'-methoxy-HCID 4596104-Chloro-6,7-dimethoxyquinoline

Product 1

HCID 24879062HCID 24879062, compoundYield 8.1%

Conditions

Temperature
180 °C

Procedure

A mixture of 4-chloro-6,7-dimethoxyquinoline (93 mg) with 2-hydroxy-5-methoxybenzophenone (462 mg) was stirred at 180° C. for 9 hr. The reaction solution was cooled to room temperature and was purified by column chromatography on silica gel using acetone-hexane to give the title compound (14 mg, yield 8%).

Workup

  1. temperatureThe reaction solution was cooled to room temperature
  2. customwas purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-2e4e47a6537841959febb3d150c4557e
Source dataset
uspto-grants-2009_07
Patent number
US07560558B2

Reaction notes

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