N,N-Dimethylethylenediamine → HCID 54400012, compound

HRID 2286019Notes

Reaction equation

HRID 2286019 reaction equation
[CH3:1][O:2][C:3](=[O:9])/[CH:4]=[CH:5]\[C:6]([OH:8])=[O:7].[CH3:10][N:11]([CH3:15])[CH2:12][CH2:13][NH2:14]>C(N(CC)CC)C>[CH3:1][O:2][C:3](=[O:9])[CH2:4][C@@H:5]([C:6]([OH:8])=[O:7])[NH:14][CH2:13][CH2:12][N:11]([CH3:15])[CH3:10]

Participants

4

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 5354456Monomethyl maleate

Product 1

HCID 54400012HCID 54400012, compoundYield 33.2%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

28.6 g (0.22 mol) of maleic acid-monomethyl ester, 40 ml of triethylamine and 17.6 g (0.20 mol) of 2-dimethylaminoethylamine are reacted in a manner analogous to that described in Example 1. Further processing according to Example 1 yields 14.5 g (33.2% of theory) of a crystalline aspartic acid derivative, which melts at 164° to 166°.

Sources & evidence

ORD record
ord-9ca0ead0fa0a4e0e9e33905e7329b27a
Source dataset
uspto-grants-1982_04
Patent number
US04326069

Reaction notes

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