Ethyl Bromide → HCID 20542077, compound

HRID 2286167Notes

Reaction equation

HRID 2286167 reaction equation
[CH2:1](Br)[CH3:2].C(=O)([O-])[O-].[K+].[K+].[C:10]([C:13]1[CH:14]=[CH:15][C:16]2[NH:22][C:21](=[O:23])[CH2:20][N:19]=[C:18]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[F:30])[C:17]=2[CH:31]=1)(=[O:12])[CH3:11]>CC(C)=O>[C:10]([C:13]1[CH:14]=[CH:15][C:16]2[N:22]([CH2:1][CH3:2])[C:21](=[O:23])[CH2:20][N:19]=[C:18]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[F:30])[C:17]=2[CH:31]=1)(=[O:12])[CH3:11]

Participants

5

Reactant 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 2327585414-BENZODIAZPN2-ON,5(2-F PH)7ACETYL

Product 1

HCID 20542077HCID 20542077, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

14.2 ml of ethyl bromide and 27.2 g of potassium carbonate are added to 13.6 b (45.9 mmol) of 7-acetyl-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one in 400 ml of acetone. The mixture is stirred at room temperature for 71 hours, filtered and evaporated in vacuo. The residue is taken up in methylene chloride, the organic phase is washed with water, dried and evaporated. From methylene chloride/cyclohexane there is obtained 7-acetyl-1-ethyl-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one of melting point 154°-156°.

Workup

  1. filtrationfiltered
  2. customevaporated in vacuo
  3. washthe organic phase is washed with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-04aa08a1305b4fa797ab397f936486d0
Source dataset
uspto-grants-1982_04
Patent number
US04327026

Reaction notes

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