Potassium Carbonate → HCID 178502888, compound

HRID 2286187Notes

Reaction equation

HRID 2286187 reaction equation
Cl.[CH3:2][O:3][NH2:4].[C:5](=[O:8])([O-])[O-].[K+].[K+].Cl.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1CCl>O>[CH3:2][O:3][N:4]=[C:5]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=1)[OH:8]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 23392Picolyl chloride hydrochlorideHCID 521874O-Methylhydroxylamine hydrochloride

Product 1

HCID 178502888HCID 178502888, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

6.8 g (0.08 mol) of an O-methylhydroxylamine hydrochloric acid salt was dissolved in 20 ml of water, and 22.4 g (0.16 mole) of potassium carbonate dissolved in 20 ml of water was dropwise added thereto at 0° C. 14.2 g (0.08 mol) of a picolinyl chloride hydrochloric acid salt was further added thereto, and the resulting solution was stirred at 0° to 10° C. for 4 hours. The reaction product thus obtained was extracted with methylene chloride several times. The organic phase was dried over anhydrous sodium sulfate to obtain 8.4 g of N-methoxypyridine-2-carboximidic acid.

Workup

  1. additionwas dropwise added
  2. customat 0° C
  3. customThe reaction product thus obtained
  4. extractionwas extracted with methylene chloride several times
  5. dry with materialThe organic phase was dried over anhydrous sodium sulfate

Sources & evidence

ORD record
ord-03eba7971abc4af190555dfce0b3f1cb
Source dataset
uspto-grants-1982_04
Patent number
US04327089

Reaction notes

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