Hydrochloric Acid → HCID 12836708, compound

HRID 2286193Notes

Reaction equation

HRID 2286193 reaction equation
[CH2:1]([N:4]1[CH:9](SC)[NH:8][C:7](=[O:12])[CH:6]=[N:5]1)[C:2]#[CH:3].Cl.C([OH:16])C>>[CH2:1]([N:4]1[C:9](=[O:16])[NH:8][C:7](=[O:12])[CH:6]=[N:5]1)[C:2]#[CH:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 20542231HCID 20542231, compound

Product 1

HCID 12836708HCID 12836708, compoundYield 82.1%

Procedure

A mixture of 1.34 g 2-propargyl-3-methylthio-5-oxo-2,3-dihydro-1,2,4-triazine, 5 ml conc. hydrochloric acid and 10 ml ethyl alcohol was heated under reflux for 1.5 hours. After cooling to room temperature, the solvent was removed under reduced pressure to obtain a yellow solid. This solid was recrystallized from ethyl alcohol to obtain 0.92 g of a white crystal.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1.5 hours
  3. customthe solvent was removed under reduced pressure
  4. customto obtain a yellow solid
  5. customThis solid was recrystallized from ethyl alcohol

Sources & evidence

ORD record
ord-af7328bf6fd84298a09e0a809e9d8877
Source dataset
uspto-grants-1982_04
Patent number
US04327094

Reaction notes

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