Methylamine → HCID 53801169, compound

HRID 2286262Notes

Reaction equation

HRID 2286262 reaction equation
CO[C:3](=[O:14])/[C:4](=[N:11]\[O:12][CH3:13])/[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1.[CH3:15][NH2:16]>O>[CH3:15][NH:16][C:3](=[O:14])[C:4](=[N:11][O:12][CH3:13])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 140335625HCID 140335625, compound

Product 1

HCID 53801169HCID 53801169, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Z-α-methoxyimino-2-pyridineacetic acid methylester (5 g) and a solution of methylamine in water (15 ml, 30%) were stirred at a temperature of 60° C. until the starting compound was completely dissolved. Water was evaporated under reduced pressure and the residue was recrystallized from toluene, yielding N-methyl-α-methoxyimino-2-pyridineacetamide (3.0 g), Z-isomer, m.p. 132°-133° C. The E-isomer was obtained in the same way, but starting from the corresponding E-ester. M.p. of the E-isomer 91°-93° C.

Workup

  1. dissolutionwas completely dissolved
  2. customWater was evaporated under reduced pressure
  3. customthe residue was recrystallized from toluene

Sources & evidence

ORD record
ord-c9c8b59f018949308c7f7a50b160304e
Source dataset
uspto-grants-1982_04
Patent number
US04327213

Reaction notes

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