Hydrogen Peroxide → HCID 20542286, compound

HRID 2286292Notes

Reaction equation

HRID 2286292 reaction equation
[C:1]1([S:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:12]=2[C:19]2[NH:20][C:21]3[C:22]([N:27]=2)=[N:23][CH:24]=[CH:25][CH:26]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.OO.C(=O)([O-])[O-:31].[K+].[K+]>C(O)(=O)C.O>[C:1]1([S:7]([CH2:8][CH2:9][O:10][C:11]2[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:12]=2[C:19]2[NH:20][C:21]3[C:22]([N:27]=2)=[N:23][CH:24]=[CH:25][CH:26]=3)=[O:31])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 20542284HCID 20542284, compound

Product 1

HCID 20542286HCID 20542286, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of 2.8 gm (0.0074 mol) of 2-[2-(2-phenylthioethoxy)-4-methoxyphenyl]imidazo[4,5-b]pyridine in 40 ml of glacial acetic acid was admixed with 0.84 gm of hydrogen peroxide (30%), and the mixture was stirred for 2 hours at room temperature. Subsequently, the reaction mixture was diluted with 20 ml of water, neutralized with potassium carbonate, extracted three times with 50 ml each of methylene chloride, and dried over magnesium sulfate. The purification was carried out on 70 gm of silicagel with methylene chloride/acetone (100:0 to 80:20).

Workup

  1. extractionextracted three times with 50 ml each of methylene chloride
  2. dry with materialdried over magnesium sulfate
  3. customThe purification

Sources & evidence

ORD record
ord-99e451a8bb1944849a4e0ff1cb83e6f9
Source dataset
uspto-grants-1982_04
Patent number
US04327100

Reaction notes

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