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Ethyl iodide (8.13 g, 0.052 mole) was added to acetone (80 ml) containing N-nitroso piperazine (6.0 g, 0.052 mole) (prepared as described in U.S. Pat. No. 2,907,767) and anhydrous potassium carbonate (7.3 g, 0.052 mole). The mixture was heated under reflux for 24 hours, cooled, treated with water (50 ml) evaporated to 1/2 volume and extracted with ether (3×150 ml). The combined extracts were dried (K2CO3) filtered and evaporated in vacuo to yield N-ethyl-N'-nitrosopiperazine (7.71 g, 98%), as a straw coloured oil.

1. customprepared
2. temperatureThe mixture was heated
3. temperatureunder reflux for 24 hours
4. temperaturecooled
5. customevaporated to 1/2 volume
6. extractionextracted with ether (3×150 ml)
7. dry with materialThe combined extracts were dried (K2CO3)
8. filtrationfiltered
9. customevaporated in vacuo