Hydrochloric Acid → HCID 15572235, compound

HRID 2286600Notes

Reaction equation

HRID 2286600 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([OH:17])([C:13]([F:16])([F:15])[F:14])[C:9]([F:12])([F:11])[F:10])[CH:5]=[C:4]([CH3:18])[C:3]=1[NH:19][CH2:20][C:21]([O:23]CC)=[O:22].Cl>[OH-].[Na+]>[C:21]([CH2:20][NH:19][C:3]1[C:2]([CH3:1])=[CH:7][C:6]([C:8]([OH:17])([C:13]([F:15])([F:14])[F:16])[C:9]([F:10])([F:11])[F:12])=[CH:5][C:4]=1[CH3:18])([OH:23])=[O:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15572222HCID 15572222, compound

Product 1

HCID 15572235HCID 15572235, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Dissolve ethyl N-[2,6-dimethyl-4-(hexafluoro-2-hydroxy-2-propyl)phenyl]glycinate (3.1 g, 8.3 mmol) in 25 ml 1.0 N NaOH. After 1 hour, add 25 ml 1.0 N HCl and extract with ethyl acetate. Dry and concentrate. Recrystallize from chloroform-benzene to give the title compound as beige solid, m.p. 153°-155° C. dec.

Workup

  1. extractionextract with ethyl acetate
  2. customDry
  3. concentrationconcentrate
  4. customRecrystallize from chloroform-benzene

Sources & evidence

ORD record
ord-cf6f348677f34fa2a6fb539f05d7caf0
Source dataset
uspto-grants-1981_05
Patent number
US04267193

Reaction notes

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